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…in many cases of tramadol dependence, a history of substance abuse is present….but….the evidence for physical dependence was considered minimal. Consequently, Tramadol is generally considered as a drug with low potential for dependence. In a recent German study (including a literature study, an analysis of two drug safety databases, and questionnaires analyses), the low abuse and low dependence potential of Tramadol were re-confirmed. The German expert group found a low prevalence of abuse or dependence in clinical practice in Germany, and concluded that Tramadol has a low potential for misuse, abuse, and dependence in Germany.[30]
Long-term use of high doses of tramadol will cause physical dependence and withdrawal syndrome.[27] These include both symptoms typical of opioid withdrawal and those associated with SNRI withdrawal; symptoms include numbness, tingling, paresthesia, and tinnitus.[28] Psychiatric symptoms may include hallucinations, paranoia, extreme anxiety, panic attacks, and confusion.[29] In most cases, tramadol withdrawal will set in 12–20 hours after the last dose, but this can vary.[28] Tramadol withdrawal typically lasts longer than that of other opioids. Seven days or more of acute withdrawal symptoms can occur as opposed to typically three or four days for other codeine analogues.[28]
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…in many cases of tramadol dependence, a history of substance abuse is present….but….the evidence for physical dependence was considered minimal. Consequently, Tramadol is generally considered as a drug with low potential for dependence. In a recent German study (including a literature study, an analysis of two drug safety databases, and questionnaires analyses), the low abuse and low dependence potential of Tramadol were re-confirmed. The German expert group found a low prevalence of abuse or dependence in clinical practice in Germany, and concluded that Tramadol has a low potential for misuse, abuse, and dependence in Germany.[30]
Long-term use of high doses of tramadol will cause physical dependence and withdrawal syndrome.[27] These include both symptoms typical of opioid withdrawal and those associated with SNRI withdrawal; symptoms include numbness, tingling, paresthesia, and tinnitus.[28] Psychiatric symptoms may include hallucinations, paranoia, extreme anxiety, panic attacks, and confusion.[29] In most cases, tramadol withdrawal will set in 12–20 hours after the last dose, but this can vary.[28] Tramadol withdrawal typically lasts longer than that of other opioids. Seven days or more of acute withdrawal symptoms can occur as opposed to typically three or four days for other codeine analogues.[28]
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