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Q: Will tramadol make your blood pressure drop? A: Tramadol (Ultram) is approved for use in adults to treat moderate to moderately severe pain. It is a centrally acting opioid analgesic (pain killer). Tramadol works by altering the way the body responds to pain, and it inhibits the reuptake of norepinephrine and serotonin. Hypotension and orthostatic hypotension are both listed as possible side effects of tramadol, according to the prescribing information.
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